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CBG

CBG EDUCATION

Not to be confused with the more popular cannabinoid, CBD, CBG is quite different yet seems to share MANY of the same properties in comparison to CBD. Interestingly, there is official dialogue among the scientific community that the potential of both CBG and its acidic form (CBGA) could actually be greater than CBD!

CBG is often described as the:

  • “stem cell cannabinoid”
  • “precursor cannabinoid”
  • mother of cannabinoids” (my personal favorite)

The nicknames alone sparked our curiosity and since most CBG articles are completely outdated with loads of misinformation, it was time for the Cannabidiol Life Team to get our research on and write the BEST FACT-BASED CBG GUIDE TO DATE (June 2020).

Let’s kick-off this Cannabigerol educational tour with an aesthetically pleasing CBG infographic!

WHAT IS CBG?

CBG is short for Cannabigerol and it is a chemical compound naturally found in Cannabis plants. This particular compound is known as a cannabinoid and since it comes from plants, you will also hear it called a phytocannabinoid (Phyto = from plants) as well.

The interesting part about CBG is that it is commonly referred to as the precursor cannabinoid or mother cannabinoid. The reason for this is because Cannabis Sativa plants produce what is called, “cannabigerolic acid” or CBGA for short.

CBGA is now understood to be the first cannabinoid produced by a cannabis plant. This cannabinoid is genetically destined to go through an enzymatic reaction when exposed to either:

  • oxygen
  • heat
  • UV rays

Exposure to oxygen and UV rays is inevitable since all cannabis plant’s physically need these elements in order to grow. 

In summary, once this exposure occurs, it will push CBGA to go through multiple enzymatic reactions which ultimately, creates all the chemical compounds/cannabinoids we know and love to take. 

(CLICK TO EXPAND)

Here are the three note-worthy enzymatic reactions & transformations:

  • CBGA will shred its acidic molecule transforming it into CBG
  • CBGA will create the acidic forms of CBD, THC & CBC
  • The two above allows for the formation of all other major cannabinoids

For this reason, CBG has been dubbed the mother of cannabinoids.

Now, since CBGA always turns into another cannabinoid, how much CBG is actually available per plant?

THE GOLDEN RULE FOR CBG CONSUMERS

Certificates of Analysis (C.O.A.), also referred to as third-party or 3rd party lab tests, are the tests CBD and CBG retailers must have to both validate the authenticity of the product and protect the buyer. C.O.A.’s tell us the potency percentage of each cannabinoid within the product being tested.

Here’s why this test is so important… told in an actual scenario that happens far too often.

You walk into the Cannabidiol Life shop and you’re here to buy CBG isolate.

Well, friends, I have 10 grams of premium CBG isolate crystalline powder that is just tickled with excitement but waiting patiently for the perfect family to go home with, what do you say?

First off, we don’t talk that way.

Second (golden rule), YOU MUST REQUEST/LOOK AT THE C.O.A.

If you’re shopping online, or as we see it “walking into our virtual store”, then you would just look at the product picture photo gallery or scan the QR code on the product label.

If you don’t see the C.O.A. on the company’s website, call the company and ask for one. If they don’t have one, or it is more than a year old, it’s probably safe to assume your health is not that company’s number one priority.

In case it was unclear, here is the GOLDEN RULE = Before you buy a cannabis product, you MUST look for the C.O.A. 

THE IMPORTANCE OF KNOWING THE CBG PERCENTAGE

Hypothetically, let’s say I’m trying to sell you 10 GRAMS OF CBG isolate; 10 grams = 10,000 MG. For educational purposes, let’s say our CBG isolate 95% pure.

Now that we have the CBG percentage, we can accurately find out how many MG’s of CBG is actually inside the 10-gram CBG isolate jar.

Next, take the products’ milligram weight (10 grams = 10,000MG) and multiply it by the CBG percentage (95%) and since we’re dealing with percentages, you have to move the decimal over to the left by two positions.

The equation will look something like this:
10,000MG x 0.95 = 9,500 MG of CBG.

This is VERY important because without knowing the Cannabinoid percentage, you will not be able to compare one CBG isolate product to the next (quality-wise). The only thing you will be able to compare is the price.

Make sense?

Far too often, CBG consumers purchase inferior products or get robbed by false label claims by simply not checking the C.O.A.’s.

The moral of this short story here is don’t assume that the listed weight on the label is an automatic reference to the amount of CBG/CBD within.  It’s all about the percentage of cannabinoid purity.

How Much CBG Is Usually Found In Cannabis Plants?

As you could likely assume, it’s not much.

In fact, according to a study completed by Research Gate, individual cannabinoid percentages were tested from five different states in hopes of gaining a better understanding of average cannabinoid percentages found in cannabis plants.

Here are the results:

  • roughly 1.4% – 1.6% of CBG
  • about 9% – 12% of CBD

Please keep in mind, this is choosing random cannabis plants and not CBG-rich specific plants. Nonetheless, you can tell why CBG is just now becoming popular in comparison to CBD. It’s a lot easier to get and vastly cheaper to produce!

HOW MUCH DOES IT COST TO MAKE A KILO OF CBG?

On September 11, 2019, Forbes posted an article that mentioned it could take up to 20 times more biomass to produce CBG in comparison to CBD. They used a 20% to 1% C.P.P.R. (Cannabis Plant Percentage Ratio) comparison of CBD to CBG to get the “20 times more biomass” figure.

Three months later on January 24, 2020, ACS Laboratory posted an article that states the average retail cost of CBG appears to be about $30,000 – $50,000 per kilo.

THESE PRICES ARE VERY INACCURATE.

The reason we were very specific about when the above articles were posted is to show you how fast things can change in the hemp industry. January 2020 was only 5-6 months ago yet those prices are considered ANCIENT facts.

While bulk CBG products can vary due to supply and demand, as of June 2020, prices for a kilo of CBG isolate can range between $4,000 – $8,500.

We wanted to offer various prices from different companies so below we will share the best prices for kilo’s of CBG isolate that is for sale online:

  • CANNABIDIOL LIFE: Offered price = $4,000.00 – $5,000 per kilo of CBG isolate (BEST PRICE)
  • THE HEMP COLLECTIVE: Offered price = $8,500.00 per kilo of CBG isolate
  • THE FRESH BRO’S: Offered price = $7,599.99 per kilo of CBG isolate

WHAT DOES CBG ACTUALLY DO?

CBG, like other cannabinoids, interacts with the brain and nervous system via the two main cannabinoid receptors in the body, specifically CB1 and CB2. CB1 is commonly associated with the nervous system and CB2 is more commonly associated with inflammation and the systems that handle that response.

This study stated that CBG significantly modulates CB2R- or CB1R/CB2R-mediated endocannabinoid action, while the effects are weak in CB1R-expressing cells and that this reveals that CBG may exert beneficial actions with therapeutic potential via cannabinoid receptors.

CBG is mainly known to function as a GABA reuptake inhibitor. This means CBG could potentially help with muscle relaxation, and relieve tension by promoting a peaceful sensation throughout the body, brain, and nervous system. Historically, GABA uptake inhibitors are already used to treat anxiety, and because of this fact, it implies that CBG could just possibly decrease anxiety symptoms. This is not a fact, just promising.

Cannabinoids are found naturally present in the human body and these are known as Endocannabinoids. Endo means, internal or coming from within. Therefore, when phytocannabinoids and endocannabinoids work together promoting better communication via these receptors, homeostasis is promoted from within.

This entire receptor and communication management system within our bodies is known as the ECS (Endocannabinoid System), which helps regulate a variety of functions including pain, appetite, and inflammation. Phytocannabinoids like CBG, CBD, THC, and CBN interact easily with this system as they share extremely similar molecular structures.

This heightened effectiveness is the result of all cannabinoids working together as a synergistic cannabinoid team effect and can only be experienced with full-spectrum CBD products or full-spectrum CBG products. This experience or more commonly referred to as an effect is known as the “entourage effect.”

We wrote a really in-depth article on this topic but for CBD!  “WHAT DOES CBD DO?” You absolutely should check it out and watch the video!

IS CBG A FULL SPECTRUM PRODUCT?

In order for a specific industrial hemp extract to be considered “full-spectrum”, the cannabinoids CBD, CBG, CBC, CBN, & THC need to be detectable. Thus, CBG alone is NOT full-spectrum.

A good rule of thumb here is that if any hemp product or cannabinoid-specific product is labeled “full-spectrum”, ALWAYS VERIFY THIS LABEL CLAIM by looking at the C.O.A. to ensure you’re getting what you are paying for!

Another tip to help you verify quality is that if CBG products or even a CBD product has the name “isolate” attached to it, it simply means that the specific cannabinoid in question has been ISOLATED from all the other phytocannabinoids and is usually sold in powder form.

WHAT ARE THE HEALTH BENEFITS OF CBG?

(BASED ON SCIENTIFIC STUDIES ON SPECIFIC MEDICAL CONDITIONS)

For this next part, we want everyone to understand one thing, we are providing you educational resources based on real scientific studies. In no way shape or form should you consider the studies below as any type of medical claim. We offer this as a service so you can make smart, educated decisions concerning your diet and health.

You are more than welcome to copy, paste, & print these resources for later use and consider showing them to your primary care physician if you have further questions about what CBG could potentially do for you. It’s important to understand that while all of these studies show promise, they are not considered medical facts and are currently deemed “unfounded” until more tests are completed to verify these preliminary study results.

Let’s begin!

CBG FOR ACNE & DRY SKIN Syndrome

  • We found this study to be very interesting and learned something new as well!  The conclusions stated that their data suggests CBG and CBGV may have potential in the treatment of dry skin syndrome.This is where we got excited (even if its not specifically concerning CBG).  The study further states that CBC, CBDV, and especially THCV showed to be highly efficient, novel anti-acne agents.

    *We are now in formulating a cannabinoid-specific acne product after stumbling upon this gem!*

 

CBG AND ANTIMICROBIAL ACTIVITY

  • https://pubmed.ncbi.nlm.nih.gov/7153877/
    Eisohly HN, Turner CE, Clark AM, Eisohly MA. Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds. J Pharm Sci. 1982;71(12):1319‐1323. doi:10.1002/jps.2600711204

 

CBG As An Appetite Stimulant

  • This 2016 study states that CBG is a well-tolerated appetite stimulant as well as that more investigation is warranted as CBG elicits hyperphagia by reducing the time it took to begin eating as well as increasing meal frequency. The same can be said with THC, but CBG offers the same promising results without producing psychotropic effects.

CBG FOR BLADDER CONTRACTILITY

  • In this study, it explains the effects of CBG specifically on acetylcholine-induced contractions and states that the contractions weren’t affected by CB1 or CB2 receptor antagonists, as well as it reduced acetylcholine-induced contractions in the human bladder.

 

CBG FOR Blood Pressure & Hypertension

CBG FOR CANCER

CBG FOR COLITIS & INFLAMMATORY BOWEL DISEASE

 

CBG FOR DEPRESSION

  • This study showed evidence that CBG could inhibit noradrenaline reuptake and if this proves to be true, it would be considered to be consistent with a preliminary report indicating that it may possess antidepressant activity.

CBG FOR GLAUCOMA

 

CBG FOR HUNTINGTON'S DISEASE

 

CBG FOR PARKINSON'S DISEASE

 

CBG FOR MRSA (ANTIBIOTIC RESISTENCE)

CBG FOR NAUSEA

  •  This study wasn’t necessarily on whether CBG could help with nausea but more so if CBG and CBD will work together or against each other as both communicate with 5-HT(1A) receptors.  The findings were expected, they may oppose each other

 

CBG FOR NEUROINFLAMMATION

CBG FOR PAIN

 

CBG FOR PSORIASIS

 

CBG SIDE EFFECTS

There is currently not enough completed research to answer this question in confidence, however, in this study, it seems as though CBG is well-tolerated by animals. We look forward to obtaining more data in order to properly answer this question for you.

HIGHEST-QUALITY CBG STRAINS (CULTIVARS)

CBG dominant strains have jumped through the roof in popularity once the 2018 Farm Bill was put into effect. Farmers nationwide were cleared to begin growing industrial hemp. This led to industry innovators pushing for the cultivation of high CBG strains. Fast forward to today, we now have industrial hemp CBG strains reaching upwards into the high teens! And the buck doesn’t stop there!

According to Oregon Seeds, their manicured CBG hemp flower batches have tested as high as almost 20% in CBG and the highest claim we’ve seen is 22% from

This is all record-breaking CBG percentages right here people!  It’s all unfolding before our eyes!

The world is pushing for a more organic lifestyle and we couldn’t be more excited about it.

Best CBG Strains List:

It sort of bothers me that the cannabis industry refuses to give up the word “strain” in reference to the different species of cannabis plants.  This prompts a “Cannabis Fast Fact” moment.

CANNABIS FAST FACT:  STRAINS are used in virology to describe genetic variants of bacteria, fungi, and viruses.  CULTIVARS, however, is short for “cultivated variety” and should be considered the go-to term when referencing cannabis plant varieties.  Another word that could replace strains is, “SUBSPECIES“.  This can be verified by leading industry news outlets such as Leafly, Plant Law, & Cannabis Now

I’ve been wanting to get that off my chest for a while. Without further ado… 

List of the best CBG strains offering the highest CBG percentages:

  1. SUPER GLUE: 22%
  2. WHITE CBG: 20%
  3. LEMON CREAM DIESEL CBG: 20%
  4. JACK FROST CBG: 17% – 18%
  5. CBGamit: 14-18% (NATURALLY BRED)
  6. THE CBG BLEND: 16%
  7. MATTERHORN CBG: 15%
  8. CBG FLOWER: 15%

We saved the best for last…

The CBG strain with the absolute highest CBG percentage we found online is called STEM CELL!  Testing at an unbelievable 99.5% CBG percentage.

The reason we saved this monster CBG cultivar for last is that we simply had to comment on the process of how CBG strains could even reach these levels of potency. It was time to, PHONE A PRO!

I interviewed 5-year United States Navy Veteran Austin Rhodes, CEO of DREEM Nutrition due to his substantial knowledge and vast experience working with top tier breeders in the cannabis space.

I asked Austin, “How is 99.5% CBG even possible?” 

This was his response:

“What’s happening is these breeders are using genetic marker-assisted breeding and they removed the THCA synthase process. It might get them what they claim percentage-wise, but it comes at a cost because it affects the plants’ immune system in a large way.”

I FOUND THIS TO BE INCREDIBLY INTERESTING!

Unfortunately, due to unclear possible side effects and the fact that I couldn’t find a COA anywhere for it, I couldn’t feature it in the Best CBG Strains List above. I would like to give them a HUGE high-five for innovation though (social distancing for COVID permitting, of course).

HOW IS CBG MADE?

Organically, CBG is created naturally during hemp plants’ natural growing lifecycle. More specifically, it is created when CBGA transforms into CBG. And this enzymatic acid breakdown occurs as the plants’ chemical compounds interact with heat, oxygen, and UV light exposure.

Now, in reference to create a CBG product, there are a few steps that must be taken. A CBG-rich hemp plant must go through an extraction process, a purification process, and then a final process to remove any remaining solvents left behind. The specific details of this process are explained in the next section.

HOW TO EXTRACT CBG

Scientists can extract higher levels of CBG from budding plants by harvesting them at the optimal extraction time. This is usually about six weeks into the eight-week cycle when the plant is flowering. Currently, in an attempt to gain higher CBG yields, breeders are experimenting with genetic manipulation and cross-breeding.

CBG is generally extracted via the supercritical CO2, ethanol, or ICP (isopropyl alcohol). If you are unfamiliar with the very extraction processes, please read our blog post on it here. Regardless of the extraction method used, a key rule of thumb here is a solvent must be used in order to reach 98%+ CBG purity.

It looks like this:

  • CBG-rich Hemp Plant Biomass will go through a supercritical CO2 extraction process, which will create Crude CBG oil.
  • This crude oil will then be purified using either ethanol or ICP solvents to further separate the CBG molecule from any other remaining plant components.
  • Once this step is completed, a vacuum oven is used to vaporize any of the remaining solvents.
  • Based on the exact equipment the chemist is using, the final product could be a full spectrum CBG distillate or pure CBG isolate.
CBG dosage 1 to 1 ratio

CBG DOSAGE:

CBG doses or serving sizes vary from 1 person to the next but we’ve found a great way to figure out the formula for each and every person wanting or at least considering adding CBG to their diets.

I spoke with Dr. Rosado, MD, and author of Hope & Healing: A Case For Cannabis, and this is what he advised…

“CBG works best when used in a 1:1 ratio with CBD.”

SHORT AND SWEET! Once we know how much CBD we should take, we’ll know exactly what our CBG dose will be. Now, in order to find the perfect CBD dosage, we must use the following CBD Dosage formula:

BODY WEIGHT X 0.325mg = Most Accurate CBD Dose

I’ll use myself as an example and show you step by step how to calculate your perfect CBG dosage. Since I weigh 200lbs, my specific formula will look like this:

200lbs x 0.325mg = 65mg of CBD

Given the 1:1 ratio (CBD to CBG), this tells me that my perfect CBG dose is 65mg and should be coupled with 65mg of CBD for the best possible results (based on current CBG research).

And that’s all there is to it!

SUGGESTED CBG USE:

A study in 2019 stated that the benefits shared between CBD and CBG are actually ENHANCED when administered together.

This is great news as it confirms with Dr. Rosado’s CBG dosage suggestion above.

Given this wonderful guidance, we recommend two options:

Here is a quick example of how to properly to option 2 since there is a bit of mixing involved.

Let’s say you’ve purchased our USDA Certified Organic full-spectrum CBD oil 1,500mg.  The next step would be to grab your CBG isolate and weight out an equal portion of mg of CBG (1,500mg).  Mix these two together and you now have a perfect 1 to 1 ratio of CBD to CBG.

Remember to calculate the CBG mg accurately using the GOLDEN RULE every CBG buyer must know in section 2 of this article concerning COA lookups and the importance of cannabinoid potencies.

Always store AWAY of direct sunlight as well as in a cool and dry place. One study showed that failure to properly store your cannabis products could actually drastically affect its quality and the consumer could lose up to 40% of the cannabinoids claimed on the bottle.

AUTHOR SUMMARY

Christopher Visser CBG

Christopher Visser
CEO of Cannabidiol Life

“CBG IS EXCITING! So is CBN oil, in my opinion. While there is clearly some anecdotal evidence that indicates the potential benefits of CBG, more research, and clinical studies are needed in order to conclusively prove its effectiveness.

 

Nonetheless, if you consume pure cannabis products in their entirety, you should be getting trace amounts of CBG in its natural form. Currently, there aren’t any reported cases of adverse side-effects to CBG. However, there’s still not enough research to say this definitely. Always check with your doctor before adding cannabinoids to your regimen.”